       Document 1006
 DOCN  M9651006
 TI    [Effects of beta-adrenergic compounds on IgE production]
 DT    9505
 AU    Coqueret O; Lagente V; Molecular Oncology group, Royal Victoria
       Hospital, McGill; University, Montreal, Quebec, Canada.
 SO    Allerg Immunol (Paris). 1995 Dec;27(10):358-62. Unique Identifier :
       AIDSLINE MED/96157219
 AB    We studied the effects of beta 2-adrenoceptor agonist on IgE production
       in vitro in human and in vitro and in vivo in mouse. We observed that
       salbutamol and fenoterol potentiate the IL-4-induced IgE production from
       peripheral blood mononuclear cells. This effect is associated by an
       enhanced mRN expression for IgE. Fenoterol also potentiated, but in a
       lesser extent, the IgE production from purified B lymphocytes stimulated
       by both IL-4 and CD40, suggesting that the activity of beta
       2-adrenoceptor agonist is mediated through T lymphocyte or monocyte
       modulation. Fenoterol also inhibited the PHA-induced IFN-gamma
       production by T lymphocytes. Analogues of cAMP or activator of PKA also
       elicited an increase in IgE production. Moreover, the effect of
       fenoterol on IgE production was suppressed in the presence of PKA
       inhibitor. Salbutamol also potentiated the IL-4-induced IgE production
       from murine splenocytes activated by LPS. Furthermore, mice sensitized
       to ovalbumin elicited increased IgE responses after daily injection of
       salbutamol. This was accompanied by an increased in cytokines of Th2
       subtypes. Our results showed that beta 2-adrenoceptor agonist, which are
       currently used in the treatment of asthma, potentiate the IgE production
       in vitro and in vivo.
 DE    Adrenergic beta-Agonists/*PHARMACOLOGY  Albuterol/PHARMACOLOGY  Animal
       Anti-Asthmatic Agents/PHARMACOLOGY  Antibody Formation/DRUG EFFECTS
       Antigens, CD40/PHYSIOLOGY  Antigens, Surface/BIOSYNTHESIS
       Cytokines/SECRETION  Drug Synergism  English Abstract
       Fenoterol/PHARMACOLOGY  Human  IgE/*BIOSYNTHESIS  Interferon Type
       II/SECRETION  Interleukin-4/PHARMACOLOGY  Lymphocyte Cooperation/DRUG
       EFFECTS  Mice  Mice, Inbred BALB C  Phytohemagglutinins/PHARMACOLOGY
       Receptors, Adrenergic, beta-2/*AGONISTS  T-Lymphocytes/DRUG
       EFFECTS/SECRETION  Th2 Cells/DRUG EFFECTS/SECRETION  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

