       Document 1004
 DOCN  M9651004
 TI    Biologically active flavonoids and terpenoids from Egletes viscosa.
 DT    9505
 AU    Lima MA; Silveira ER; Marques MS; Santos RH; Gambardela MT; Curso de
       Pos-Graduacao em Quimica Organica, Departamento de; Quimica Organica e
       Inorganica, Laboratorio de Produtos; Naturais, Universidade Federal do
       Ceara, Fortaleza, Brazil.
 SO    Phytochemistry. 1996 Jan;41(1):217-23. Unique Identifier : AIDSLINE
       MED/96165758
 AB    The steam volatile components from the hexane extract of dried flower
       buds of Egletes viscosa were identified by gas chromatography-mass
       spectrometry as trans-carvyl acetate, cis-carvyl acetate, sabinyl
       acetate, verbenyl acetate, cyclopentaethylidene, geranyl acetate and
       5-methylfuranone, and trans-pinocarvyl acetate (major component). From
       the non-volatile residue, centipedic acid and a novel clerodane
       diterpene, 12-acetoxy-hawtriwaic acid lactone, were isolated. From the
       ethanol extract, ternatin (4',5-dihidroxy-3,3',7,8-tetramethoxyflavone),
       was isolated. Ternatin showed anti-inflammatory, hepatoprotection and
       gastroprotection properties, and, according to the NCI protocols, it
       showed moderate activity against HIV. The diterpenes showed
       antispasmodic activity. Structure determination of these secondary
       metabolites was accomplished by spectrometric methods, including 2D NMR,
       chemical interconversion and X-ray crystallographic analysis.
 DE    Anti-Inflammatory Agents, Non-Steroidal/CHEMISTRY/ISOLATION &
       PURIF/PHARMACOLOGY  Antiviral Agents/*CHEMISTRY/ISOLATION &
       PURIF/PHARMACOLOGY  Brazil  Comparative Study  Crystallography, X-Ray
       Diterpenes/CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY
       Flavones/*CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  Human  HIV/*DRUG
       EFFECTS  Medicine, Traditional  Models, Molecular  Molecular Structure
       Nuclear Magnetic Resonance  Parasympatholytics/CHEMISTRY/ISOLATION &
       PURIF/PHARMACOLOGY  Plant Extracts  *Plants, Medicinal
       Structure-Activity Relationship  Support, Non-U.S. Gov't
       Terpenes/*CHEMISTRY/ISOLATION & PURIF/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

