       Document 0966
 DOCN  M9650966
 TI    DIPLOMO: the tool for a new type of evolutionary analysis.
 DT    9505
 AU    Weiller GF; Gibbs A; Research School of Biological Science, Australian
       National; University, Camberra, Australia.
       weiller@rsbscentral.anu.edu.au
 SO    Comput Appl Biosci. 1995 Oct;11(5):535-40. Unique Identifier : AIDSLINE
       MED/96163633
 AB    A package of computer programs called DIPLOMO (DIstance PLOt MOnitor)
       has been developed for making pairwise comparisons of different
       estimates of the distances between a set of taxa by plotting them
       against each other in a simple scatter plot. Taxa with similar relative
       distance characteristics are thereby grouped graphically. Groupings of
       different taxa may be directly identified, and the distance
       characteristics of chosen groups visualised and compared using devices
       to give them different colours or symbols. The program is particularly
       useful for detecting and analysing subtle trends in gene sequence
       evolution. This is done by comparing different components of change, for
       example synonymous versus non-synonymous nucleotide changes,
       transversions versus transitions and changes in different genes of the
       same set of taxa, etc. The program has a wide range of other uses, for
       example comparing different methods of sequence analysis, assessing
       which components of genetic change correlate best with phenotypic change
       or with geographical separation. This paper describes the DIPLOMO
       package, and illustrates typical DIPLOMO analyses using lentivirus gene
       sequence data.
 DE    Evaluation Studies  *Evolution  Genes, env  Genetic Techniques
       HIV-1/GENETICS  HIV-2/GENETICS  *Software  Species Specificity
       SIV/GENETICS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

