       Document 0945
 DOCN  M9650945
 TI    Intestinal microsporidiosis with Septata intestinalis in a patient with
       AIDS--response to albendazole.
 DT    9505
 AU    Franzen C; Muller A; Schwenk A; Salzberger B; Fatkenheuer G; Mahrle G;
       Diehl V; Schrappe M; Department of Internal Medicine I, University of
       Cologne,; Germany.
 SO    J Infect. 1995 Nov;31(3):237-9. Unique Identifier : AIDSLINE
       MED/96163971
 AB    Microsporidiosis is a common finding in HIV-infected patients who have
       diarrhoea. The species most commonly causing gastrointestinal disease is
       Enterocytozoon bieneusi. Recently Septata intestinalis has been
       described as a cause of diarrhoea and disseminated infection in patients
       with AIDS. A 44-year-old homosexual man with severe immunodeficiency
       (CD4 cell count 40/microliters) had a history of watery diarrhoea for 2
       weeks. Microsporidian spores measuring 1.2 to 1.5 x 2.5 to 3.0 microns
       were found in stool samples. Electron microscopy of duodenal biopsies
       confirmed the diagnosis of intestinal microsporidiosis and showed
       parasitophorous vacuoles with the typical ultrastructure of S.
       intestinalis. The patient was treated with albendazole (400 mg twice
       daily) and became asymptomatic within 4 days. No spores could be
       detected in stool samples after a treatment period of 14 days. About 25
       infections with S. intestinalis have been reported to date, and the case
       presented here is the first in a German patient.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult
       Albendazole/*THERAPEUTIC USE  Animal  Anthelmintics/*THERAPEUTIC USE
       AIDS-Related Opportunistic Infections/DRUG THERAPY/*PARASITOLOGY  Case
       Report  Diarrhea/DRUG THERAPY/*PARASITOLOGY  Homosexuality, Male  Human
       Male  Microscopy, Electron  Microspora/GROWTH &
       DEVELOPMENT/*ULTRASTRUCTURE  Microspora Infections/DRUG
       THERAPY/*PARASITOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

