       Document 0919
 DOCN  M9650919
 TI    Ultrastructural findings in the cochlea of AIDS cases.
 DT    9505
 AU    Pappas DG Jr; Chandra f1p4ar HK; Lim J; Hillman DE; Department of
       Otolaryngology, NYU Medical Center, NY 10016, USA.
 SO    Am J Otol. 1994 Jul;15(4):456-65. Unique Identifier : AIDSLINE
       MED/96148973
 AB    Neurotologic manifestations associated with the human immunodeficiency
       virus (HIV-1) are poorly understood. Eight temporal bones of acquired
       immunodeficiency syndrome (AIDS) cases were dissected and investigated
       ultrastructurally to determine if pathogens and pathologic changes were
       present within the cochlea. Extracellular viral-like particles with
       morphologic characteristics of HIV-1 were identified on the tectorial
       membrane in three cases. Numerous viral-like particles with cores
       appeared trapped within lacunae along the tectorial membrane in one
       specimen. Intracellular viral-like particles, appearing essentially
       similar to identified HIV-1 particles of infected lymphocyte cultures,
       were found within the cytoplasm of connective tissue cells. These same
       cells had gradients of enlarged viral envelopes forming cisterns that
       contained cores and varying amounts of cistern particulate. Some
       sectioned profiles of enlarged cytoplasmic cisterns revealed the
       attachment and inward protrusion of the core from the cistern wall.
       Other ultrastructural findings included cytoplasmic globular-dense
       particulate bodies, aggregates of smaller viral-like particles, and
       mitochondrial changes. This demonstration of prominent viral-like
       particles and cochlear pathology may help to explain the neurotologic
       manifestations associated with HIV-1 infection.
 DE    Adult  Cadaver  Cochlea/PATHOLOGY/ULTRASTRUCTURE/*VIROLOGY  Female
       Human  HIV Infections/*PATHOLOGY  HIV-1/*ISOLATION &
       PURIF/ULTRASTRUCTURE  Male  Microscopy, Electron  Middle Age  Temporal
       Bone  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

