       Document 0918
 DOCN  M9650918
 TI    The ear in the acquired immunodeficiency syndrome: I. Temporal bone
       histopathologic study.
 DT    9505
 AU    Michaels L; Soucek S; Liang J; Department of Histopathology, UCL Medical
       School, London, UK.
 SO    Am J Otol. 1994 Jul;15(4):515-22. Unique Identifier : AIDSLINE
       MED/96148980
 AB    A postmortem histopathologic investigation of temporal bones of patients
       with the acquired immunodeficiency syndrome (AIDS) was performed after
       microslicing, acid decalcification of the slices and paraffin embedding.
       Histopathologic changes in 49 temporal bones from 25 patients included
       severe otitis media in five patients (20%), low-grade otitis media in
       fifteen (60%), labyrinthine cryptococcosis in two, Kaposi's sarcoma
       deposit in the eighth nerve of one, and cytomegalovirus (CMV)
       inclusion-bearing cells in the inner and middle ear of six (24%). It was
       possible to identify the CMV genome by in situ hybridization in only two
       bones and expression of CMV antigen by immunohistochemistry in none,
       probably because of prolonged decalcification in acid. The ear is no
       less susceptible to AIDS-associated diseases than any other organ, and
       is particularly prone to CMV infection.
 DE    Acoustic Nerve/PATHOLOGY  Acquired Immunodeficiency
       Syndrome/COMPLICATIONS/*PATHOLOGY  Adult  AIDS-Related Opportunistic
       Infections/*PATHOLOGY  Cadaver  Cranial Nerve
       Diseases/ETIOLOGY/PATHOLOGY  Cryptococcosis/ETIOLOGY/*PATHOLOGY
       Cytomegalovirus Infections/ETIOLOGY/*PATHOLOGY  Ear, Middle/PATHOLOGY
       Female  Human  Immunohistochemistry  Labyrinth/PATHOLOGY  Male  Middle
       Age  Otitis Media/ETIOLOGY/*PATHOLOGY  Temporal Bone/*PATHOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

