       Document 0913
 DOCN  M9650913
 TI    [A new oxa-analog of myristic acid, suppressing replication of the human
       immunodeficiency virus]
 DT    9505
 AU    Vodovozova EL; Mikhalev II; Rzhaninova AA; Garaev MM; Molotkovskii IuG
 SO    Bioorg Khim. 1995 Sep;21(9):724-30. Unique Identifier : AIDSLINE
       MED/96072057
 AB    A series of oxaanalogs of myristic acid were synthesized and tested for
       antiviral activity in MT4 cells infected with human immunodeficiency
       virus 1 (HIV-1). The synthesized acids have no toxic effect on
       uninfected MT4 cells at a concentration of 100 microM.
       14,14,14-Trifluoro-12-oxatetradecanoic acid substantially (by 75%)
       inhibits the reproduction of HIV-1. Other compounds synthesized,
       (7Z)-13-, (9Z)-13-, and (7Z)-11-oxatetradecenoic acids, exhibit no
       antiviral effect.
 DE    Antiviral Agents/CHEMISTRY/CHEMICAL SYNTHESIS/*PHARMACOLOGY  Cell Line
       English Abstract  HIV-1/*DRUG EFFECTS/PHYSIOLOGY  Microbial Sensitivity
       Tests  Myristic Acids/CHEMISTRY/CHEMICAL SYNTHESIS/*PHARMACOLOGY
       Oxygen/CHEMISTRY  Virus Replication/*DRUG EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

