       Document 0527
 DOCN  M9640527
 TI    Peripheral blood lymphocyte subsets in patients with stomach cancer.
 DT    9604
 AU    Hong WS; Min YI; Son YS; Hong SI; Department of Internal Medicine, Asan
       Medical Center, University; of Ulsan, Seoul, Korea.
 SO    J Korean Med Sci. 1995 Jun;10(3):164-8. Unique Identifier : AIDSLINE
       MED/96089674
 AB    The present study was conducted in order to investigate the immunologic
       alterations alongside the numerical changes in peripheral blood
       lymphocytes(PBL) and their subsets in stomach cancer patients.
       Lymphocyte surface markers were determined in 85 stomach cancer patients
       and 49 controls by indirect immunofluorescence technique using
       monoclonal antibodies. Monoclonal antibodies used were Leu 2a(CD8,
       suppressor/cytotoxic T cells), Leu 3a(CD4, inducer/helper T cells), Leu
       4(CD3, pan T reagent), Leu 11(CD16, natural killer cells) and Leu
       12(CD19, B cells). The numbers of PBL, CD3+, CD4+, CD8+, CD16+ and CD19+
       cells significantly decreased and the CD4: CD8 value increased in 85
       patients with stomach cancer compared to those in controls(p < 0.01). In
       stage I(n = 17), neither PBL, their subsets nor the CD4: CD8 value were
       significantly different from those of the controls. In stage II(n = 17),
       the numbers of PBL, CD3+, CD4+ and CD8+ cells decreased(p < 0.01). In
       stage III(n = 24) and IV(n = 27), PBL and all subsets measured
       decreased(p < 0.01). The CD4: CD8 value showed significant increases in
       stages III and IV(p < 0.01), because the CD8+ cells decreased to a
       greater extent than did the CD4+ cells. The results demonstrating that
       the lymphocyte subsets are depressed differentially with the stage
       suggest that host immunity is impaired with the progression of stomach
       cancer.
 DE    Adult  Age Distribution  Aged  Antigens, CD19/ANALYSIS  Antigens,
       CD3/ANALYSIS  CD4-Positive T-Lymphocytes/CYTOLOGY  CD8-Positive
       T-Lymphocytes/CYTOLOGY  Female  Human  Lymphocyte Count  Lymphocyte
       Subsets/CHEMISTRY/*IMMUNOLOGY  Male  Middle Age  Receptors, IgG/ANALYSIS
       Sex Distribution  Stomach Neoplasms/BLOOD/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

