       Document 0524
 DOCN  M9640524
 TI    Comparative assessment of small intestinal and colonic permeability in
       HIV-infected homosexual men.
 DT    9604
 AU    Obinna FC; Cook G; Beale T; Dave S; Cunningham D; Fleming SC; Claydon E;
       Harris JW; Kapembwa MS; Booth Research Laboratory, St Mary's Hospital
       Medical School,; Harrow, UK.
 SO    AIDS. 1995 Sep;9(9):1009-16. Unique Identifier : AIDSLINE MED/96085715
 AB    OBJECTIVES: To investigate both small and large intestinal permeability
       in HIV-positive subjects, and correlate variation in intestinal mucosal
       abnormality with immunological and nutritional markers of HIV disease.
       METHODS: Small and large intestinal permeability studies were performed
       in 14 HIV-seropositive patients and eight healthy men. Eight out of the
       14 patients had diarrhoea and all subjects were negative for
       enteropathogens. Small intestinal permeability was determined using the
       lactulose-mannitol test and large intestinal permeability using the
       colonic absorption of 51Cr-EDTA. In addition, CD4 cell count, beta
       2-microglobulin, C-reactive protein estimation and anthropometry were
       carried out in all subjects. RESULTS: HIV-seropositive subjects had
       higher lactulose-mannitol ratios (LMR; 0.084 +/- 0.007 versus 0.013 +/-
       0.0008) and lower 51Cr activity (1.986 +/- 0.066 versus 3.115 +/- 0.560)
       than controls (P < 0.0004 and P < 0.05, respectively). Colonic uptake of
       51Cr-EDTA was no different between subjects with and those without
       diarrhoea (2.04 +/- 0.124 versus 1.92 +/- 0.143, P > 0.05). A negative
       correlation was found between LMR and 51Cr-EDTA, but only for patients
       with diarrhoea (r = -0.81; P = 0.015). CONCLUSION: Regional variation
       affecting intestinal absorptive function occurs in patients with
       HIV-related diarrhoea and is characterized by increased LMR and reduced
       colonic uptake of 51Cr-EDTA. The pathogenesis and clinical significance
       of such changes are unknown.
 DE    Adult  AIDS-Related Opportunistic Infections/DIAGNOSIS/PHYSIOPATHOLOGY
       Colon/PHYSIOPATHOLOGY  CD4 Lymphocyte Count  Diarrhea/PHYSIOPATHOLOGY
       Homosexuality, Male  Human  HIV Infections/DIAGNOSIS/*PHYSIOPATHOLOGY
       HIV Seropositivity/DIAGNOSIS/PHYSIOPATHOLOGY  Intestinal
       Absorption/*PHYSIOLOGY  Intestinal Mucosa/*PHYSIOPATHOLOGY  Intestine,
       Small/PHYSIOPATHOLOGY  Male  Middle Age  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

