       Document 0519
 DOCN  M9640519
 TI    Micronutrients and HIV-1 disease progression.
 DT    9604
 AU    Baum MK; Shor-Posner G; Lu Y; Rosner B; Sauberlich HE; Fletcher MA;
       Szapocznik J; Eisdorfer C; Buring JE; Hennekens CH; Department of
       Epidemiology and Public Health, University of Miami; School of Medicine,
       Florida 33101, USA.
 SO    AIDS. 1995 Sep;9(9):1051-6. Unique Identifier : AIDSLINE MED/96085720
 AB    OBJECTIVE: To determine whether nutritional status affects immunological
       markers of HIV-1 disease progression. DESIGN: A longitudinal study, to
       evaluate the relationship between plasma levels of nutrients and CD4
       cell counts, along and in combination with beta 2-microglobulin (beta
       2M; AIDS index) over an 18-month follow-up. METHODS: Biochemical
       measurements of nutritional status including plasma proteins, zinc, iron
       and vitamins B1, B2, B6, B12 (cobalamin), A, E, C and folate and
       immunological markers [lymphocyte subpopulations (CD4) and beta 2M] were
       obtained in 108 HIV-1-seropositive homosexual men at baseline and over
       three 6-month time periods. Changes in nutrient status (e.g., normal to
       deficient, deficient to normal), were compared with immunological
       parameters in the same time periods using an autoregressive model.
       RESULTS: Development of deficiency of vitamin A or vitamin B12 was
       associated with a decline in CD4 cell count (P = 0.0255 and 0.0377,
       respectively), while normalization of vitamin A, vitamin B12 and zinc
       was associated with higher CD4 cell counts (P = 0.0492, 0.0061 and
       0.0112, respectively). These findings were largely unaffected by
       zidovudine use. For vitamin B12, low baseline status significantly
       predicted accelerated HIV-1 disease progression determined by CD4 cell
       count (P = 0.041) and the AIDS index (P = 0.005). CONCLUSIONS: These
       data suggest that micronutrient deficiencies are associated with HIV-1
       disease progression and raise the possibility that normalization might
       increase symptom-free survival.
 DE    beta 2-Microglobulin/METABOLISM  Adult  Blood Proteins/METABOLISM  *CD4
       Lymphocyte Count  Disease Progression  Follow-Up Studies  Human  HIV
       Infections/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Longitudinal Studies  Male
       Middle Age  *Nutritional Status  Support, U.S. Gov't, P.H.S.  Trace
       Elements/*BLOOD  Vitamin A Deficiency/IMMUNOLOGY  Vitamin B 12
       Deficiency/IMMUNOLOGY  Vitamins/*BLOOD  Zinc/BLOOD/DEFICIENCY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

