       Document 0518
 DOCN  M9640518
 TI    HIV-1 and immunological changes during pregnancy: a comparison between
       HIV-1-seropositive and HIV-1-seronegative women in Nairobi, Kenya.
 DT    9604
 AU    Temmerman M; Nagelkerke N; Bwayo J; Chomba EN; Ndinya-Achola J; Piot P;
       Department of Obstetrics and Gynaecology, University of Ghent,; Belgium.
 SO    AIDS. 1995 Sep;9(9):1057-60. Unique Identifier : AIDSLINE MED/96085721
 AB    OBJECTIVE: To assess changes in the proportion of CD4 and CD8
       T-lymphocyte profiles during pregnancy, at delivery and postpartum, and
       to determine whether HIV-1 infection affects the normal profile. DESIGN
       AND METHODS: A total of 416 pregnant HIV-1-infected women and an age and
       parity-matched HIV-seronegative group of 407 pregnant women were
       enrolled into a prospective study on the impact of HIV-1 infection on
       pregnancy. Maternal blood was obtained for lymphocyte subset
       determination at enrollment, delivery and 6 weeks postpartum. Whole
       blood sample drawn in EDTA-containing tubes were used to determine
       T-helper/inducer (CD4) and T-suppressor/cytotoxic (CD8) cells by direct
       immunofluorescence using monoclonal antibodies. RESULTS: No relationship
       was found between gestational age and any immunological variable. The
       CD4 percentage was lower postpartum than antenatally, in both
       HIV-1-seropositive and seronegative women, but this was not true for
       absolute CD4 counts. CD8 absolute counts and percentages were
       significantly higher postpartum than antenatally. The differences
       between HIV-1-seropositive and seronegative women in changes over
       pregnancy in CD4 and CD8 cells and their ratio, were not statistically
       significant. CONCLUSION: Our findings do not support a short-term
       synergistic effect of HIV-1 and pregnancy on the immune function as
       determined by T-lymphocyte subsets.
 DE    Adult  CD4 Lymphocyte Count  CD4-CD8 Ratio  *Developing Countries
       Female  Gestational Age  Human  HIV Seronegativity/*IMMUNOLOGY  HIV
       Seropositivity/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Kenya  Pregnancy
       Pregnancy Complications, Infectious/*IMMUNOLOGY  Prospective Studies
       Puerperal Infection/IMMUNOLOGY  *Urban Population  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

