       Document 0488
 DOCN  M9640488
 TI    Aspergillus sinusitis in patients with AIDS: report of three cases and
       review.
 DT    9604
 AU    Teh W; Matti BS; Marisiddaiah H; Minamoto GY; Division of Allergy,
       Clinical Immunology, and Infectious; Diseases, St. Luke's/Roosevelt
       Hospital Center, New York, New; York 10025, USA.
 SO    Clin Infect Dis. 1995 Sep;21(3):529-35. Unique Identifier : AIDSLINE
       MED/96077368
 AB    Invasive aspergillosis is an uncommon but increasingly reported
       complication of AIDS. Sinusitis, usually bacterial in etiology, is
       frequently seen among human immunodeficiency virus (HIV)-infected
       patients. We discuss the cases of three patients with AIDS and invasive
       aspergillus sinusitis seen at our institutions and those of 15 patients
       who are described in the literature. Seven of the 18 had brain
       involvement, 3 had orbital involvement, and 7 had mastoid or other bony
       disease. Three had evidence of concomitant invasive pulmonary
       aspergillosis. Of 15 patients with evaluable histories, 11 had
       recognized risks for invasive aspergillosis; 6 had previous sinusitis,
       otitis, or polyposis; and 11 had prior conditions indicative of advanced
       HIV-related disease. Despite aggressive surgical intervention and
       systemic antifungal therapy, nearly all patients died as a result of
       aspergillosis.
 DE    Adolescence  Adult  Antifungal Agents/THERAPEUTIC USE
       Aspergillosis/*COMPLICATIONS/DRUG THERAPY/SURGERY  AIDS-Related
       Opportunistic Infections/*COMPLICATIONS/DRUG THERAPY/  SURGERY  Case
       Report  Combined Modality Therapy  Female  Human  Lung Diseases,
       Fungal/COMPLICATIONS  Male  Middle Age  Prognosis
       Sinusitis/*COMPLICATIONS/DRUG THERAPY/SURGERY  JOURNAL ARTICLE  REVIEW
       REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

