       Document 0486
 DOCN  M9640486
 TI    Transmission of zidovudine-resistant human immunodeficiency virus type 1
       variants following deliberate injection of blood from a patient with
       AIDS: characteristics and natural history of the virus.
 DT    9604
 AU    Veenstra J; Schuurman R; Cornelissen M; van't Wout AB; Boucher CA;
       Schuitemaker H; Goudsmit J; Coutinho RA; Department of Public Health and
       Environment, Municipal Health; Service, Amsterdam, the Netherlands.
 SO    Clin Infect Dis. 1995 Sep;21(3):556-60. Unique Identifier : AIDSLINE
       MED/96077373
 AB    We describe the development and persistence of severe immunodeficiency
       in a previously healthy young woman shortly after she was deliberately
       injected with blood that was drawn from a patient with AIDS. The
       heterogenous populations of human immunodeficiency virus (HIV) in donor
       and recipient were as closely related as those reported in previous
       cases of proven transmission. The relatively large proportion of
       non-syncytium-inducing (NSI) clones in the recipient suggests a
       selective but not complete suppression of syncytium-inducing (SI)
       viruses. The continuous presence of SI viruses might explain the severe
       immunosuppression that persisted once the recipient seroconverted. A
       codon 215 mutation (indicative of zidovudine resistance) was present in
       SI and NSI clones of the donor and in NSI clones of the recipient. The
       relative increase in codon 215 resistance mutation in the absence of
       zidovudine therapy was secondary to the increase in NSI clones. Findings
       in this case suggest that qualities of an inoculum and/or the route of
       transmission are important determinants in the subsequent clinical
       course of HIV disease.
 DE    Adult  Case Report  Drug Resistance, Microbial/GENETICS  Female  Human
       HIV Infections/ETIOLOGY/*TRANSMISSION/VIROLOGY  HIV Seropositivity
       *HIV-1/DRUG EFFECTS/GENETICS  Mutation  Polymerase Chain Reaction  Time
       Factors  Zidovudine/PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

