       Document 0485
 DOCN  M9640485
 TI    Transmission of fluconazole-resistant Candida albicans between patients
       with AIDS and oropharyngeal candidiasis documented by pulsed-field gel
       electrophoresis.
 DT    9604
 AU    Barchiesi F; Hollis RJ; Del Poeta M; McGough DA; Scalise G; Rinaldi MG;
       Pfaller MA; Department of Pathology, University of Texas Health Science;
       Center, San Antonio 78284-7750, USA.
 SO    Clin Infect Dis. 1995 Sep;21(3):561-4. Unique Identifier : AIDSLINE
       MED/96077374
 AB    Electrophoretic karyotype and restriction endonuclease analysis of
       genomic DNA were used for the typing of nine isolates of Candida
       albicans from the oral cavities of two patients with AIDS--a husband and
       wife--whose infections became resistant to treatment with fluconazole
       (400 mg/d). The in vitro susceptibilities of sequential isolates to
       fluconazole and two other triazoles, itraconazole and the
       investigational drug D0870, were also evaluated. DNA analysis showed
       that the isolates responsible for fluconazole-resistant episodes of
       oropharyngeal candidiasis in the two patients were genetically related.
       In vitro susceptibility to fluconazole correlated well with clinical
       outcome. Although the minimal inhibitory concentrations of itraconazole
       and D0870 for fluconazole-resistant isolates were higher than those for
       fluconazole-susceptible isolates, both of the former triazoles exhibited
       good in vitro activity against the isolates tested.
 DE    Adult  AIDS-Related Opportunistic Infections/DRUG THERAPY/MICROBIOLOGY/
       *TRANSMISSION  Candida albicans/DRUG EFFECTS/GENETICS/ISOLATION & PURIF
       Candidiasis, Oral/*COMPLICATIONS/DRUG THERAPY/*TRANSMISSION  Case Report
       Drug Resistance, Microbial  DNA, Fungal/GENETICS/ISOLATION & PURIF
       Electrophoresis, Gel, Pulsed-Field  Female  Fluconazole/PHARMACOLOGY
       Human  Male  Pharyngeal Diseases/*COMPLICATIONS/DRUG
       THERAPY/MICROBIOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

