       Document 0483
 DOCN  M9640483
 TI    Clinical presentation of minimally invasive and in situ squamous cell
       carcinoma of the anus in homosexual men.
 DT    9604
 AU    Forti RL; Medwell SJ; Aboulafia DM; Surawicz CM; Spach DH; Department of
       Medicine, University of Washington Medical Center,; Seattle, USA.
 SO    Clin Infect Dis. 1995 Sep;21(3):603-7. Unique Identifier : AIDSLINE
       MED/96077381
 AB    From January 1988 to December 1993, we identified six men with minimally
       invasive (stage I) squamous cell carcinoma of the anus and 10 men with
       anal carcinoma in situ (CIS). Of the six patients with invasive
       carcinoma, four were infected with human immunodeficiency virus (HIV),
       including one with AIDS. Of the 10 patients with CIS, eight were
       infected with HIV, including four with AIDS. Anal pain and bleeding were
       the most common symptoms of minimally invasive anal cancer and anal CIS.
       Anal irritation, burning, or pruritus occurred more frequently in
       patients with CIS, whereas anal ulcers, masses, or abscesses were more
       frequent in patients with minimally invasive cancer. Several patients
       with CIS had a discrete area of leukoplakia in the anal canal or a
       pigmented plaque of the anus and anal canal. These lesions were not
       observed in patients with minimally invasive anal cancer. The symptoms
       and signs of early-stage anal cancer in men at risk for developing HIV
       infection or men infected with HIV often resemble those of other common
       anorectal diseases in homosexual men. Anal cancer in HIV-infected men is
       not limited to those individuals with AIDS.
 DE    Adult  Anus Neoplasms/COMPLICATIONS/DIAGNOSIS/*ETIOLOGY  Carcinoma in
       Situ/COMPLICATIONS/DIAGNOSIS/*ETIOLOGY  Carcinoma, Squamous
       Cell/COMPLICATIONS/DIAGNOSIS/*ETIOLOGY  Homosexuality, Male  Human  HIV
       Infections/COMPLICATIONS  Male  Risk Factors  Support, U.S. Gov't,
       P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

