       Document 0482
 DOCN  M9640482
 TI    Pulmonary cryptococcosis: localized and disseminated infections in 27
       patients with AIDS.
 DT    9604
 AU    Meyohas MC; Roux P; Bollens D; Chouaid C; Rozenbaum W; Meynard JL;
       Poirot JL; Frottier J; Mayaud C; Service des Maladies Infectieuses et
       Tropicales, Hopital; Saint-Antoine, Paris, France.
 SO    Clin Infect Dis. 1995 Sep;21(3):628-33. Unique Identifier : AIDSLINE
       MED/96077385
 AB    We reviewed the records of 85 patients infected with both human
       immunodeficiency virus and Cryptococcus neoformans. Twenty-seven
       patients (32%) had pulmonary cryptococcosis. C. neoformans was cultured
       from bronchoalveolar lavage (BAL) or pleural fluid in 25 cases; the
       remaining two patients had cryptococcal antigen (CA) detected in BAL
       fluid and C. neoformans cultured from other sites. All but one of the 27
       patients had detectable CA in serum. The CD4+ lymphocyte count was low
       in all cases (median, 24/mm3). Clinical manifestations of pulmonary
       cryptococcosis included fever (94%), cough (71%), dyspnea (7%),
       expectoration (4%), chest pain (2%), and hemoptysis (1%). Diffuse
       interstitial opacities (70.5%), focal interstitial abnormalities,
       alveolar opacities, adenopathies, cavitary lesions, and pleural
       effusions were evident. Outcome was poor (mean survival time, 23 weeks)
       despite treatment. Patients with localized pulmonary cryptococcosis
       appeared to have a higher CD4+ lymphocyte count, an earlier diagnosis,
       lower serum CA titers, fewer previous or concomitant infections, and a
       better prognosis than patients with disseminated cryptococcosis.
 DE    Adult  Antigens, Fungal/ISOLATION & PURIF  AIDS-Related Opportunistic
       Infections/*DIAGNOSIS/IMMUNOLOGY  Bronchoalveolar Lavage
       Fluid/IMMUNOLOGY/MICROBIOLOGY
       Cryptococcosis/*COMPLICATIONS/DIAGNOSIS/IMMUNOLOGY  Cryptococcus
       neoformans/IMMUNOLOGY/ISOLATION & PURIF  CD4 Lymphocyte Count  Female
       Human  Lung Diseases, Fungal/*COMPLICATIONS/DIAGNOSIS/IMMUNOLOGY  Male
       Middle Age  Prognosis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

