       Document 0481
 DOCN  M9640481
 TI    Emergence of multidrug resistance in Campylobacter jejuni isolates from
       three patients infected with human immunodeficiency virus.
 DT    9604
 AU    Tee W; Mijch A; Wright E; Yung A; Victorian Infectious Diseases
       Reference Laboratory, Fairfield; Hospital, Victoria, Australia.
 SO    Clin Infect Dis. 1995 Sep;21(3):634-8. Unique Identifier : AIDSLINE
       MED/96077386
 AB    Single-drug resistance to tetracycline, doxycycline, erythromycin, or
       fluoroquinolones in Campylobacter isolates recovered from humans has
       been documented worldwide. Multidrug resistance to these antibiotics is
       rare in Campylobacter jejuni. We report the sequential development of
       multidrug resistance in C. jejuni isolates from three patients who were
       infected with human immunodeficiency virus. Multiple isolates recovered
       from stool specimens from these patients were ribotyped, and antibiotic
       susceptibility profiles were determined. The results indicated that each
       patient was infected with a single strain of C. jejuni that had
       progressively acquired resistance to the antibiotics used during
       treatment. The emergence of resistant isolates appeared to correlate
       with clinical relapse. In these patients, campylobacter enteritis was
       prolonged, severe, and relapsing, and antimicrobial therapy was
       required. Once these first-line antibiotics become ineffective, few
       other antibiotics are available for treating patients with campylobacter
       enteritis. Acquisition of antibiotic resistance in C. jejuni is
       therefore of concern in these cases.
 DE    Adult  Anti-Infective Agents, Fluoroquinolone/PHARMACOLOGY  Antibiotics,
       Macrolide/PHARMACOLOGY  AIDS-Related Opportunistic Infections/DRUG
       THERAPY/*MICROBIOLOGY  Campylobacter jejuni/*DRUG EFFECTS/ISOLATION &
       PURIF  Campylobacter Infections/*COMPLICATIONS/DRUG THERAPY/MICROBIOLOGY
       Case Report  Ciprofloxacin/PHARMACOLOGY  Doxycycline/PHARMACOLOGY  *Drug
       Resistance, Multiple  Enteritis/*COMPLICATIONS/DRUG THERAPY/MICROBIOLOGY
       Erythromycin/PHARMACOLOGY  Human  Male  Tetracycline Resistance  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

