       Document 0444
 DOCN  M9640444
 TI    Survival of AIDS patients in the emerging epidemic in Bangkok, Thailand.
 DT    9604
 AU    Kitayaporn D; Tansuphaswadikul S; Lohsomboon P; Pannachet K; Kaewkungwal
       J; Limpakarnjanarat K; Mastro TD; HIV/AIDS Collaboration, Nonthaburi,
       Thailand.
 SO    J Acquir Immune Defic Syndr Hum Retrovirol. 1995 Jan 1;11(1):77-82.
       Unique Identifier : AIDSLINE MED/96130050
 AB    Survival from the time of AIDS diagnosis to death was determined
       retrospectively among Thai patients (> or = 13 years old) who attended a
       public tertiary care infectious disease hospital in a suburb of Bangkok,
       Thailand, from February 1987 through February 1993. An AIDS diagnosis
       was based on the 1987 Centers for Disease Control (CDC) definition,
       except Penicillium marneffei infection was included as an AIDS-defining
       condition. Of 329 AIDS patients, 152 (46.2%) had died. The median age at
       diagnosis was 31.5 years (range, 18-74) 306 patients (93.0%) were males.
       Reported risk categories were heterosexual contact (55.2%), injecting
       drug use (IDU, 22.6%), male homosexual or bisexual contact (9.5%), and
       unidentified risk or other (12.7%). Median survival time (Kaplan-Meier)
       for all patients was 7.0 months; 1-year survival probability was 39.2%
       (95% confidence interval [CI] = 31.5-46.9%). Cox's proportional hazards
       model showed three factors associated with survival: age, reported risk
       category, and presenting diagnosis. Patients aged 26 to 35 years
       survived longer (median survival time, 10.6 months; relative hazard [RH]
       = 0.61, 95% CI = 0.44-0.85, referent: others), as did patients in sexual
       risk categories (median survival time, 7.3 months; RH = 0.59, 95% CI =
       0.40-0.78, referent: IDU and other categories). A single presenting
       diagnosis of extrapulmonary tuberculosis was also associated with longer
       survival (median survival time, 19.9 months, RH = 0.55, 95% CI =
       0.35-0.86, referent: other diagnoses). AIDS patients in the early phase
       of the epidemic in Bangkok have much shorter survival times than
       patients in developed countries, in part perhaps because they are often
       diagnosed late in the course of HIV infection. Increased attention
       should be given to the early diagnosis and treatment of these patients.
 DE    Acquired Immunodeficiency Syndrome/*MORTALITY  Adolescence  Adult  Aged
       Disease Outbreaks/*STATISTICS & NUMER DATA  Female  Human  Lymphocyte
       Count  Male  Middle Age  Probability  Proportional Hazards Models
       Retrospective Studies  Risk Factors  Survival Analysis
       Thailand/EPIDEMIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

