       Document 0418
 DOCN  M9640418
 TI    [Viruses and cancer: molecular pathologic mechanisms of viral
       carcinogenesis]
 DT    9604
 AU    Butz K; Hoppe-Seyler F; Forschungsschwerpunkt Angewandte Tumorvirologie,
       Abteilung; Virus-Wirtszell-Wechselwirkungen, Deutsches;
       Krebsforschungszentrum Heidelber.
 SO    Immun Infekt. 1995 Oct;23(5):179-84. Unique Identifier : AIDSLINE
       MED/96091789
 AB    At least 15% of the human cancer incidence is caused by an infection
       with human tumor viruses. The recent progress of experimental cancer
       research led to important new concepts about the pathomechanisms of
       viral carcinogenesis. The functional inactivation of cellular tumor
       suppressor proteins by viral factors appears to be a key event in the
       process of virus-associated malignant cell transformation. This review
       summarizes the current concepts about the interaction between viral
       oncoproteins and cellular tumor suppressor proteins and evaluates their
       significance for individual tumor viruses and their associated cancers.
 DE    Cell Transformation, Viral  English Abstract  Gene Expression
       Regulation, Viral  *Genes, Suppressor, Tumor  Hepatitis B
       Virus/PATHOGENICITY  Herpesvirus 4, Human/PATHOGENICITY  Human
       HTLV-I/PATHOGENICITY  *Oncogenes  Oncogenic Viruses/*PATHOGENICITY
       Papillomavirus/PATHOGENICITY  Protein p53/PHYSIOLOGY  Retinoblastoma
       Protein/PHYSIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, ACADEMIC

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

