       Document 0400
 DOCN  M9640400
 TI    Central venous catheter infection with Rhodotorula minuta in a patient
       with AIDS taking suppressive doses of fluconazole.
 DT    9604
 AU    Goldani LZ; Craven DE; Sugar AM; Department of Medicine, Boston
       University Medical Center, MA; 02118, USA.
 SO    J Med Vet Mycol. 1995 Jul-Aug;33(4):267-70. Unique Identifier : AIDSLINE
       MED/96034427
 AB    A case of Rhodotorula minuta central venous catheter infection with
       fungaemia is described in a patient with advanced acquired
       immunodeficiency syndrome (AIDS), HIV nephropathy, end-stage renal
       disease requiring haemodialysis, and a permanent Quinton catheter in
       place for 6 months. At the time of fungaemia, the patient was taking 100
       mg fluconazole per os daily for a previous episode of Candida
       oesophagitis. R. minuta central venous catheter infection with fungaemia
       was successfully treated with 455 mg total dose amphotericin B (0.6 mg
       kg-1 day-1) over 25 days without removal of the catheter. In vitro
       antifungal susceptibility testing for R. minuta revealed a minimum
       inhibitory concentration to fluconazole of > 100 micrograms ml-1 and to
       amphotericin B of 1.2 microgram ml-1. Clinically evident fungaemia, even
       with an unusual organism such as R. minuta, may occur in patients with
       intravenous catheters, and while the immunosuppressed patient is
       receiving azole therapy.
 DE    Adult  Amphotericin B/*THERAPEUTIC USE  Antifungal Agents/*THERAPEUTIC
       USE  AIDS-Related Opportunistic Infections/DRUG THERAPY/*MICROBIOLOGY/
       PREVENTION & CONTROL  Candidiasis/PREVENTION & CONTROL  Case Report
       *Catheterization, Central Venous  Esophageal
       Diseases/MICROBIOLOGY/PREVENTION & CONTROL  Fluconazole/*THERAPEUTIC USE
       Fungemia/DRUG THERAPY/*ETIOLOGY  Hemodialysis  Human  HIV Seropositivity
       Kidney Failure, Chronic/ETIOLOGY/THERAPY  Male  *Rhodotorula/ISOLATION &
       PURIF  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

