       Document 0387
 DOCN  M9640387
 TI    [Detection of retrovirus in salivary glands of patients with Sjogren's
       syndrome]
 DT    9604
 AU    Yamano S; Saito I; Department of Oral Surgery, Tokyo Medical College.
 SO    Nippon Rinsho. 1995 Oct;53(10):2456-60. Unique Identifier : AIDSLINE
       MED/96021737
 AB    As similar symptoms and glandular pathology are observed in certain
       persons infected with human immunodeficiency virus (HIV) and human T
       lymphotropic virus type I (HTLV-I), a search was initiated for a
       possible retroviral etiology in Sjogren's syndrome (SS). Sera from 33%
       of 15 SS patients reacted against p24 (gag) of HIV. Salivary gland (SG)
       biopsy specimens from 47% of the 15 SS patients contained an epithelial
       cytoplasmic protein, reactive with a monoclonal antibody to p24 of HIV.
       We also detected Mn2+ dependent, Mg2+ independent reverse transcriptase
       activity in the SG 3 of 10 SS patients. Target genes for HIV and HTLV-I
       were not found in any of the SG or peripheral blood mononuclear cells
       from SS patients. These data suggest the presence of an unknown
       retrovirus, similar to HIV, in the SG, which could contribute to the
       chronic inflammation of SS.
 DE    Animal  English Abstract  Human  Retroviridae/*ISOLATION & PURIF
       RNA-Directed DNA Polymerase/METABOLISM  Salivary Glands/*VIROLOGY
       Sjogren's Syndrome/ETIOLOGY/*VIROLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

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