       Document 0386
 DOCN  M9640386
 TI    [Exocrinopathy resembling Sjogren's syndrome induced by a murine
       retrovirus]
 DT    9604
 AU    Suzuki K; Fujiwara M; Third Department of Internal Medicine, Niigata
       University.
 SO    Nippon Rinsho. 1995 Oct;53(10):2461-6. Unique Identifier : AIDSLINE
       MED/96021738
 AB    Recently, retrovirus is suggested to participate in the pathogenesis of
       Sjogren's syndrome (SjS). During the course of our study on mice
       infected with LP-BM5 murine leukemia virus, we found SjS-like systemic
       exocrinopathy in those mice. This virus is known to induce murine
       acquired immunodeficiency syndrome (MAIDS) in sensitive strains of mice.
       Most cells infiltrating into the glands were composed of CD3+ T cells
       (CD4-dominant), Mac-1+ cells and also B220+ cells. The virus genome was
       detected in the submandibular glands by immunohistochemistry or by PCR
       and the retroviral particles were also detected by electron microscopy.
       This mice might become an animal model for SjS and provide us with
       valuable informations for analysing the mechanism of how a retrovirus
       could induce SjS.
 DE    Animal  Disease Models, Animal  English Abstract  Human  Leukemia
       Viruses, Murine/*ISOLATION & PURIF  Mice  Murine Acquired
       Immunodeficiency Syndrome/PATHOLOGY  Sjogren's
       Syndrome/ETIOLOGY/*VIROLOGY  Submandibular Gland/VIROLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

