       Document 0385
 DOCN  M9640385
 TI    [HTLV-I infection in primary Sjogren's syndrome--epidemiological,
       clinical and virological studies]
 DT    9604
 AU    Eguchi K; Mizokami A; Katamine S; First Department of Internal Medicine,
       Nagasaki University School; of Medicine.
 SO    Nippon Rinsho. 1995 Oct;53(10):2467-72. Unique Identifier : AIDSLINE
       MED/96021739
 AB    The HTLV-I seroprevalence rate among the patients with Sjogren's
       syndrome (SjS, 23.0%) was significantly higher than that among blood
       donors (3.4%). The age-adjusted summary odds ratio of HTLV-I infection
       among SjS patients as compared with blood donors was 3.1. The etiologic
       fraction, i.e., the proportion of SjS in the study population that are
       attributable to HTLV-I infection, was estimated to be 17.6%. Titers of
       serum antibodies to HTLV-I in the seropositive SjS patients were
       significantly higher than those among healthy carriers. IgM class
       antibodies were commonly detected in sera of SjS patients. Salivary IgA
       class antibodies were common among seropositive SjS patients, but not in
       HAM patients or in healthy subjects. The findings strongly suggest that
       HTLV-I is involved in the pathogenesis of the disease in a subset of
       patients with SjS in endemic areas.
 DE    Adolescence  Adult  Aged  English Abstract  Female  Human  HTLV-I
       Antibodies/ANALYSIS  HTLV-I
       Infections/*COMPLICATIONS/DIAGNOSIS/EPIDEMIOLOGY  Male  Middle Age
       Sjogren's Syndrome/EPIDEMIOLOGY/*ETIOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

