       Document 0384
 DOCN  M9640384
 TI    [Expression of sequences homologous to HTLV-I pXIV gene in the labial
       salivary glands of Japanese patients with Sjogren's syndrome and
       pathogenesis]
 DT    9604
 AU    Yonaha-Nagato F; Sumida T; Division of Dermatology, Sakura Hospital,
       Toho University School; of Medicine.
 SO    Nippon Rinsho. 1995 Oct;53(10):2473-8. Unique Identifier : AIDSLINE
       MED/96021740
 AB    To address the question of whether the human T cell leukemia virus type
       I (HTLV-I) gene is associated with the etiology of Sjogren's syndrome
       (SS), RNA expression of HTLV-I gag, pol, env, and tax genes in labial
       salivary glands (LSGs) from SS patients who were seronegative for
       antibodies to HTLV-I was examined using RT-PCR method. The HTLV-I tax
       gene, but not the HTLV-I gag, pol, or env genes, was detected in LSG
       samples from 4 of 14 patients (29%). The nucleotide sequences of the
       HTLV-I pXIV region in these 4 patients' LSGs showed 100% homology to the
       HTLV-I pXIV gene from the MT-2 cell line. In conclusion, these findings
       suggest that products encoding sequences homologous to the HTLV-I pXIV
       gene in SS patients' LSGs might be candidates for self-antigen and/or
       lead to activation of autoreactive T lymphocytes through trans-acting
       transcriptional activation.
 DE    Base Sequence  English Abstract  Gene Expression Regulation, Viral
       *Genes, Viral  Human  HTLV-I/*GENETICS  Japan  Molecular Sequence Data
       Mongoloid Race  Polymerase Chain Reaction  RNA, Viral/ANALYSIS  Salivary
       Glands/*VIROLOGY  Sequence Homology, Nucleic Acid  Sjogren's
       Syndrome/*ETIOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

