       Document 0381
 DOCN  M9640381
 TI    Leukocyte adhesion molecules as a cofactor in AIDS: basic science and
       pilot study.
 DT    9604
 AU    Allen AD; Hart DN; Hechinger MK; Slattery MJ; Chesson CV 2nd; Vidikan P;
       CytoDyn of New Mexico, Inc., Santa Fe 87501, USA.
 SO    Med Hypotheses. 1995 Aug;45(2):164-8. Unique Identifier : AIDSLINE
       MED/96104083
 AB    It is well known that the AIDS pandemic is a consequence of pandemic HIV
       infection. However, Koch's postulates are not satisfied for two reasons:
       1) AIDS cannot be experimentally produced in animals susceptible to HIV
       infection and 2) some people have AIDS (idiopathic CD4+ T
       lymphocytopenia) in the absence of HIV infection. It follows that there
       is a human immunologic cofactor (HIC) that causes AIDS when certain
       other conditions are satisfied, and the most common of these other
       conditions (but not the only one) is HIV infection. Results from
       microbiology make leukocyte adhesion molecules a good candidate for the
       HIC. We have tested this hypothesis with a pilot study in which a small
       number of patients with HIV disease were infused with a monoclonal mouse
       antibody (MmAb) directed against an LFA-1 adhesion epitope, and then
       with F(ab) and F(ab)2' fragments that bind to the same epitope but are
       nonimmunogenic. Both agents reduced peripheral viral burden
       significantly but fragments were more effective in this respect than the
       MmAb due to the mitogenic properties of the latter. For the same reason,
       only the MmAb were highly effective in raising circulating levels of
       single and double-marked CD4+ T lymphocytes, with a correlated
       resolution of cutaneous anergy.
 DE    Acquired Immunodeficiency Syndrome/*IMMUNOLOGY/*THERAPY  Adult  Animal
       Antibodies, Monoclonal/*THERAPEUTIC USE  CD4 Lymphocyte Count
       Epitopes/IMMUNOLOGY  Homosexuality, Male  Human  HIV/ISOLATION & PURIF
       Immunotherapy  Lymphocyte Function-Associated Antigen-1/*IMMUNOLOGY
       Male  Mice/IMMUNOLOGY  Models, Biological  Pilot Projects  Polymerase
       Chain Reaction  RNA, Viral/BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

