       Document 0374
 DOCN  M9640374
 TI    Directions in HIV/AIDS research. A Minnesota perspective.
 DT    9604
 AU    Henry K; Melroe H; Nelson R; HIV/AIDS Clinic and Programs,
       Health-Partners St. Paul-Ramsey; Medical Center, USA.
 SO    Minn Med. 1995 Nov;78(11):26-34. Unique Identifier : AIDSLINE
       MED/96102650
 AB    Clinical studies involving HIV therapeutics are becoming ever more
       challenging because of the changing epidemiology of HIV infection, the
       rapid evolution of standard clinical practice, and a more difficult
       economic environment for research. Recent studies relating to HIV
       pathogenesis have provided novel insights into the interactions between
       HIV, the immune system, and antiretroviral therapies. Current dogma now
       suggests that the interaction of HIV and the immune system is an
       incredibly dynamic process. HIV is an intimidating pathogen capable of
       replicating quickly and mutating very rapidly in response to
       antiretroviral therapy. An important question being studied by
       Minnesota-based investigators is how well plasma analysis reflects
       HIV-immune system interactions in the lymphoid tissue where most virus
       and CD4+ (T-helper) cells are located. Most of the HIV clinical studies
       in Minnesota are conducted under the auspices of the AIDS Clinical
       Trials Group (ACTG) or the AIDS Research Consortium of the Twin Cities
       (ARCTiC). Much expertise is available in Minnesota addressing a wide
       range of topics, from epidemiology, to basic virology, to prevention. To
       optimize patient access to clinical studies, we recommend that
       physicians discuss available clinical studies with an HIV investigator
       soon after first seeing a new HIV-infected patient.
 DE    Acquired Immunodeficiency Syndrome/DRUG THERAPY/*IMMUNOLOGY/  VIROLOGY
       Antiviral Agents/ADVERSE EFFECTS/THERAPEUTIC USE  Clinical Trials  CD4
       Lymphocyte Count  Human  HIV/GENETICS  HIV Infections/DRUG
       THERAPY/*IMMUNOLOGY/VIROLOGY  Minnesota  Virus
       Replication/GENETICS/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW  REVIEW,
       TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

