       Document 0368
 DOCN  M9640368
 TI    Case-control study of HIV seroconversion in health-care workers after
       percutaneous exposure to HIV-infected blood--France, United Kingdom, and
       United States, January 1988-August 1994.
 DT    9604
 SO    MMWR Morb Mortal Wkly Rep. 1995 Dec 22;44(50):929-33. Unique Identifier
       : AIDSLINE MED/96127950
 AB    Health-care workers (HCWs) are potentially at risk for human
       immunodeficiency virus (HIV) infection through occupational exposures to
       blood. Although prospective studies indicate that the estimated risk for
       HIV infection after a percutaneous exposure to HIV-infected blood is
       approximately 0.3% (1,2), factors that influence this risk have not been
       determined. To assess potential risk factors, CDC, in collaboration with
       French and British public health authorities, conducted a retrospective
       case-control study using data reported to national surveillance systems
       in the United States, France, and the United Kingdom. This report
       describes the study and summarizes results that suggest that risk
       factors for HIV transmission include certain characteristics of the
       exposure and the source patient; in addition, postexposure use of
       zidovudine (ZDV) by HCWs was associated with a lower risk for HIV
       transmission.
 DE    Antiviral Agents/THERAPEUTIC USE  Blood-Borne Pathogens  Case-Control
       Studies  Disease Transmission, Patient-to-Professional/*STATISTICS &
       NUMER  DATA  France/EPIDEMIOLOGY  Great Britain/EPIDEMIOLOGY  Health
       Personnel/*STATISTICS & NUMER DATA  Human  HIV Infections/BLOOD/DRUG
       THERAPY/TRANSMISSION  HIV Seropositivity/DRUG
       THERAPY/*EPIDEMIOLOGY/*TRANSMISSION  Needlestick Injuries  Occupational
       Exposure  Risk Factors  United States/EPIDEMIOLOGY
       Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

