       Document 0355
 DOCN  M9640355
 TI    Repeatedly positive human immunodeficiency virus type 1 DNA polymerase
       chain reaction in human immunodeficiency virus-exposed seroreverting
       infants.
 DT    9604
 AU    Bakshi SS; Tetali S; Abrams EJ; Paul MO; Pahwa SG; Department of
       Pediatrics, North Shore University Hospital,; Cornell University Medical
       College, Manhasset, NY, USA.
 SO    Pediatr Infect Dis J. 1995 Aug;14(8):658-62. Unique Identifier :
       AIDSLINE MED/96016429
 AB    Three human immunodeficiency virus type 1 (HIV-1)-exposed children who
       had repeatedly positive DNA polymerase chain reaction (PCR) tests for
       HIV in > or = 5 samples before seroreversion to HIV-negative status are
       reported. The children belong to a cohort of 210 infants who were born
       to HIV-infected mothers and were tested at intervals of 1 to 3 months by
       HIV viral culture, PCR, and p24 antigen; only the PCR was positive in >
       or = 5 samples in the children reported here. Their clinical features
       were indistinguishable from other seroreverters. All three children had
       a transient drop in CD4:CD8 ratio to < 1.0. The transiently positive DNA
       PCR in HIV-exposed infants may indicate either that HIV infection was
       eliminated by a strong host immune response or that infection was caused
       by an attenuated/defective strain of virus.
 DE    Cohort Studies  CD4-CD8 Ratio  *Disease Transmission, Vertical  DNA,
       Viral/*ANALYSIS  Enzyme-Linked Immunosorbent Assay  Female  Follow-Up
       Studies  Human  HIV Core Protein p24/ANALYSIS  *HIV
       Seropositivity/CONGENITAL/DIAGNOSIS/IMMUNOLOGY/TRANSMISSION
       *HIV-1/GENETICS/IMMUNOLOGY  Infant  Infant, Newborn  Male  Polymerase
       Chain Reaction  Remission, Spontaneous  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

