       Document 0347
 DOCN  M9640347
 TI    [Serum hepatitis B markers: atypical patterns detected at the Hospital
       Insular de Gran Canaria]
 DT    9604
 AU    Santana OE; Frances A; Sierra A; Hernandez J; Martin-Sanchez AM;
       Servicio de Microbiologia, Hospital Insular de Gran Canaria,; Facultad
       de Ciencias de la Salud, Universidad de Las Palmas de; Gran Canaria.
 SO    Rev Clin Esp. 1995 Oct;195(10):674-7. Unique Identifier : AIDSLINE
       MED/96103232
 AB    Two atypical serological markers of hepatitis B virus (HBV) infection
       were detected in 19 patients during a 18-month period study. Pattern 1
       (10 patients) was consistent with HBV-2 infection. Reactivity of HbsAG
       was confirmed by neutralization tests; the absence of other markers was
       also verified, included anti-HBcIgM. Three of the patients were
       classified in high risk groups and seven in the low risk groups for
       hepatitis B; in none of them was co-infection with hepatitis A virus
       (HAV) detected. Pattern 2 (9 patients) was characterized by the
       detection of HBsAg and HBeAg and the absence of other hepatitis B
       markers. Six of these patients were HIV-positive patients and had
       increased and persistent levels (for longer than 12 weeks) of these
       markers. In the three remaining patients (with no underlying
       immunological disorders) there was a loss of these markers within a
       variable time (2 days to 16 weeks). Nevertheless, DNA-VHB was detected
       in one of these serum samples once all markers of virus B had
       disappeared.
 DE    Adolescence  Adult  Aged  Biological Markers/BLOOD  DNA, Viral/BLOOD
       English Abstract  Female  Hepatitis B/*DIAGNOSIS  Hepatitis B e
       Antigens/BLOOD  Hepatitis B Surface Antigens/BLOOD  Hepatitis B
       Virus/GENETICS  Hospitals, General  Human  Male  Middle Age  Spain  Time
       Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

