       Document 0344
 DOCN  M9640344
 TI    Activation of bronchoalveolar lavage T lymphocytes and clinical,
       functional and radiological features in sarcoidosis.
 DT    9604
 AU    Schoenfeld N; Schmitt M; Remy N; Ellensohn P; Loddenkemper R; Wahn U;
       Lungenklinik Heckeshorn, Kinderklinik KAVH; (Humboldt-Universitat),
       Berlin, Germany.
 SO    Sarcoidosis. 1995 Sep;12(2):135-9. Unique Identifier : AIDSLINE
       MED/96105964
 AB    Previous studies on the relationship between activated BAL T lymphocytes
       and clinical features in sarcoidosis revealed controversial results. We
       determined lavage lymphocytes, T lymphocytes, activated T lymphocytes,
       helper, suppressor and natural killer cells in 50 patients with
       pulmonary sarcoidosis and compared the results with clinical findings,
       serum angiotensin converting enzyme (ACE), the radiological pattern and
       lung function data (vital capacity [VC], total lung capacity [TLC],
       FEV1, transfer coefficient KCO and arterial-alveolar oxygen difference
       [AaDO2] during exercise). Patients with erythema nodosum (n = 7) showed
       a lower proportion of activated T lymphocytes (p < 0.05) and lymphocytes
       (p < 0.01) than the other patients. There was a significant correlation
       between activated T lymphocytes and AaDO2 during exercise (r = 0.49, p <
       0.001), and an inverse correlation was seen between activated T
       lymphocytes and VC or TLC (r = -0.35 and r = -0.36, p < 0.01). We
       conclude that the percentage of activated BAL T cells may be related to
       the degree of parenchymal involvement as expressed by functional
       disturbance.
 DE    Adult  Aged  Bronchoalveolar Lavage Fluid/*CYTOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female
       Forced Expiratory Volume  Human  Killer Cells, Natural/IMMUNOLOGY
       Lung/*PHYSIOPATHOLOGY  *Lymphocyte Transformation  Male  Middle Age
       Oxygen/BLOOD  Peptidyl-Dipeptidase A/BLOOD
       Sarcoidosis/IMMUNOLOGY/*PHYSIOPATHOLOGY/*RADIOGRAPHY
       T-Lymphocytes/*IMMUNOLOGY  Total Lung Capacity  Vital Capacity  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

