       Document 0342
 DOCN  M9640342
 TI    Difference in clinical implications of CD4 counts among HIV-infected
       homosexual men and injection drug using men and women.
 DT    9604
 AU    Paik MC; Begg MD; el-Sadr W; Gorman J; Stien Z; Division of
       Biostatistics, School of Public Health, Columbia; University, NY, NY,
       10032, USA.
 SO    Stat Med. 1995 Sep 15;14(17):1889-900. Unique Identifier : AIDSLINE
       MED/96090736
 AB    While the relationship between CD4 counts and clinical symptoms is well
       established among homosexual men, the same is not true for injection
       drug using men and women (IDUM and IDUW). In this paper we investigate
       whether CD4 counts have the same clinical implications for IDUM and IDUW
       as for homosexual men. We estimated the CD4 counts at which 50 per cent
       of the HIV-infected but AIDS-free population has AIDS related complex
       (ARC) based on three biannually measured CD4 counts. The analyses
       involve interval, right and left censored threshold data. We took the
       parametric approach, assuming that the threshold values for ARC arise
       from a family of distributions that includes symmetric, left or right
       skewed distributions, in which the logistic and extreme value
       distributions are embedded as special cases. The resulting estimates of
       median thresholds of CD4 counts for ARC were 249, 424 and 755 for
       homosexual men, IDUM, and IDUW, respectively. The results were robust
       with respect to the assumptions on the underlying distribution.
 DE    Acquired Immunodeficiency Syndrome/DIAGNOSIS/IMMUNOLOGY  Adult
       AIDS-Related Complex/IMMUNOLOGY  Confidence Intervals  *CD4 Lymphocyte
       Count  Female  Follow-Up Studies  *Homosexuality, Male  Human  HIV
       Seropositivity/DIAGNOSIS/*IMMUNOLOGY  Male  Models, Statistical
       Reference Values  Substance Abuse, Intravenous/*IMMUNOLOGY  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

