       Document 0339
 DOCN  M9640339
 TI    Detection of antibodies to HIV-1 gp41- and HLA class II antigen-derived
       peptides in SLE patients.
 DT    9604
 AU    Koshino K; Tokano Y; Hishikawa T; Sekigawa I; Takasaki Y; Hashimoto H;
       Department of Medicine, Juntendo University School of Medicine,; Tokyo,
       Japan.
 SO    Scand J Rheumatol. 1995;24(5):288-92. Unique Identifier : AIDSLINE
       MED/96106379
 AB    A role for viruses in the pathogenesis of human autoimmune diseases has
       long been suspected but has not yet been proven. Highly conserved
       homologous regions has been reported in the carboxy terminus of human
       immunodeficiency virus (HIV)-1 gp41 (amino acids 838-844) and the
       amino-terminal of the beta chain of all human HLA class II antigens
       (amino acids 19-25). This molecular mimicry between HIV-1 and HLA class
       II antigens may lead to the generation of autoantibodies and may
       contribute to the development of autoimmune phenomena in HIV infected
       patients. We detected antibodies for these homologous peptides from HLA
       class II and HIV-1 gp41 in systemic lupus erythematosus (SLE) patients
       without HIV-1 infection. Thirty-seven percent of the SLE patients had
       IgM antibodies reacting with both HLA class II- and HIV-1 gp41-derived
       peptides. These results suggest the possibility that a retrovirus may be
       one of the causative agents of SLE.
 DE    Adult  Autoantibodies/*ANALYSIS  Enzyme-Linked Immunosorbent Assay
       Female  Histocompatibility Antigens Class II/*IMMUNOLOGY  Human  HIV
       Envelope Protein gp41/*IMMUNOLOGY  IgG/ANALYSIS  IgM/ANALYSIS  Lupus
       Erythematosus, Systemic/*IMMUNOLOGY/PHYSIOPATHOLOGY  Male  Middle Age
       Molecular Mimicry  Peptide Fragments/CHEMISTRY/*IMMUNOLOGY  Reference
       Values  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

