       Document 0337
 DOCN  M9640337
 TI    The immunopathology of unilateral vasectomy in the ram.
 DT    9604
 AU    Jessop TS; Ladds PW; Department of Biomedical and Tropical Veterinary
       Sciences, James; Cook University of North Queensland, Townsville,
       Australia.
 SO    Vet Immunol Immunopathol. 1995 Jul;47(1-2):123-33. Unique Identifier :
       AIDSLINE MED/96138917
 AB    This study investigated the relationship between the local (spermatic
       granuloma) and systemic events after unilateral vasectomy in six rams.
       Spermatic microgranulomas were first observed at 4 weeks post vasectomy
       (PV), at which time lymphocytes, chiefly CD4+ (helper/inducer) cells,
       were incorporated into the periphery of the phagocytic wall. Although
       plasma cells accumulated around blood vessels near these early
       granulomas, they were not incorporated into them. All sectioned vas
       deferens contained additional microscopic spermatic granulomas away from
       the point of sectioning, as did one-third of cauda epididymides on the
       vasectomised side. There were significant (P < 0.001) increases in
       T-lymphocytes, especially CD4 cells and plasma cells (chiefly
       IgG-containing) within the granulomas at each successive PV interval.
       Concurrent enzyme-linked immunosorbent assay indicated initial presence
       of IgG and IgM antisperm antibody in serum between 2 and 4 weeks PV.
       There were significant increases of IgG (P < 0.01) and IgM (P < 0.001)
       throughout the experiment but IgA antisperm antibody was negligible.
 DE    Animal  Antibodies, Monoclonal  Autoantibodies/ANALYSIS
       Autoimmunity/IMMUNOLOGY  B-Lymphocytes/IMMUNOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Enzyme-Linked Immunosorbent Assay/VETERINARY
       Epididymis/IMMUNOLOGY/PATHOLOGY  Genital Diseases,
       Male/IMMUNOLOGY/PATHOLOGY/*VETERINARY
       Granuloma/IMMUNOLOGY/PATHOLOGY/*VETERINARY  IgG/ANALYSIS  IgM/ANALYSIS
       Lymphocyte Count/VETERINARY  Male  Sheep/SURGERY  Sheep
       Diseases/*IMMUNOLOGY/PATHOLOGY  Spermatozoa/IMMUNOLOGY  Vas
       Deferens/IMMUNOLOGY/PATHOLOGY  Vasectomy/ADVERSE EFFECTS/*VETERINARY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

