       Document 0332
 DOCN  M9640332
 TI    Transcriptional regulation of cellular and viral promoters by the
       hepatitis C virus core protein.
 DT    9604
 AU    Ray RB; Lagging LM; Meyer K; Steele R; Ray R; Division of Infectious
       Disease and Immunology, Saint Louis; University Health Sciences Center,
       MO 63110-0250, USA.
 SO    Virus Res. 1995 Aug;37(3):209-20. Unique Identifier : AIDSLINE
       MED/96136654
 AB    The genomic region encoding the hepatitis C virus (HCV) core protein was
       cloned into a mammalian expression vector to study its role on the
       transcriptional regulation of cellular proto-oncogene and viral
       promoters. Using a transient transfection assay in human hepatocellular
       carcinoma (HepG2) cells, we demonstrate that the HCV core protein
       activates the human c-myc, Rous sarcoma virus long terminal repeat
       (LTR), and simian virus 40 (SV40) early promoters; and suppresses the
       c-fos promoter and human immunodeficiency virus type 1 (HIV-1) LTR
       activity. The transcriptional regulation of cellular proto-oncogenes by
       the HCV core protein suggests possible involvement of the core protein
       in the deregulation of normal hepatocyte growth and
       hepatocarcinogenesis.
 DE    Animal  Base Sequence  DNA Primers  *Gene Expression Regulation, Viral
       Hepatitis C Viruses/*GENETICS  Human  HIV Long Terminal Repeat
       HIV-1/GENETICS  Mice  Molecular Sequence Data  Polyomavirus
       macacae/GENETICS  *Promoter Regions (Genetics)  Proto-Oncogene Proteins
       c-fos/GENETICS  Proto-Oncogene Proteins c-myc/GENETICS  Repetitive
       Sequences, Nucleic Acid  Sarcoma Viruses, Avian/GENETICS  Support, U.S.
       Gov't, P.H.S.  Transcription, Genetic  Tumor Cells, Cultured  Viral Core
       Proteins/ANALYSIS/*GENETICS  3T3 Cells  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

