       Document 0322
 DOCN  M9640322
 TI    T-lymphocyte subsets and prolonged diarrhea in young children from
       Guinea-Bissau.
 DT    9604
 AU    Molbak K; Lisse IM; Aaby P; Epidemiology Research Unit, Danish
       Epidemiology Science Centre,; Statens Seruminstitut, Copenhagen,
       Denmark.
 SO    Am J Epidemiol. 1996 Jan 1;143(1):79-84. Unique Identifier : AIDSLINE
       MED/96129944
 AB    In a community-based prospective study of 380 children conducted between
       1987 and 1990, the rate of diarrhea was significantly associated with
       percentage of CD8 T-lymphocytes and the CD4:CD8 ratio. After adjustment
       for age and previous diarrhea, the relative incidence of diarrhea with a
       duration of > or = 7 days was 2.10 (95% confidence interval (CI)
       1.15-3.85) in children with 20-29.9% CD8 T-cells and 3.41 (95% CI
       1.29-9.01) in children with > or = 30% CD8 T-cells (in comparison with
       children who had less than 20% CD8 cells) (p for trend = 0.004). There
       was a nonsignificant tendency for rates of diarrhea of > or = 7 days to
       decrease according to increasing proportions of CD4 cells (p = 0.194).
       The authors found no significant association between T-cell subsets and
       diarrhea which resolved within 6 days. The association between the
       incidence of prolonged diarrhea and T-cell subset proportions could not
       be explained as a confounding effect of low weight, breastfeeding, or
       previous infection with measles or Cryptosporidium. However, other prior
       infections or micronutrient deficiencies may explain the findings, and
       these host factors may be significant targets in intervention against
       diarrheal diseases.
 DE    Child, Preschool  CD4 Lymphocyte Count  CD4-CD8 Ratio  CD4-Positive
       T-Lymphocytes/*IMMUNOLOGY  CD8-Positive T-Lymphocytes/*IMMUNOLOGY
       Diarrhea/*EPIDEMIOLOGY/ETIOLOGY/IMMUNOLOGY  Diarrhea,
       Infantile/*EPIDEMIOLOGY/ETIOLOGY/IMMUNOLOGY  Female
       Guinea-Bissau/EPIDEMIOLOGY  Human  Incidence  Infant  Infant, Newborn
       Lymphocyte Count  Male  Multivariate Analysis  Prospective Studies  Risk
       Factors  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

