       Document 0313
 DOCN  M9640313
 TI    Serodiagnosis of Helicobacter pylori infection in patients with human
       immunodeficiency virus infection.
 DT    9604
 AU    Nielsen H; Andersen LP; Department of Infectious Diseases, Hvidovre
       University Hospital,; Copenhagen, Denmark.
 SO    APMIS. 1995 Oct;103(10):689-92. Unique Identifier : AIDSLINE
       MED/96125696
 AB    In contrast to the established role of Helicobacter pylori gastritis in
       gastritis and duodenal ulcer in general, conflicting results have been
       reported in patients with human immunodeficiency virus (HIV) infection
       and the acquired immunodeficiency syndrome. The seroprevalence during
       early HIV infection is unknown. We retrospectively studied 102 patients
       with HIV infection early during the infection and in most cases in
       asymptomatic patients. Serological IgG antibody response to H. pylori
       was assessed by ELISA. Compared with an age-matched control group the
       seroprevalence of H. pylori positivity was not significantly different
       (19% vs 25%). We observed no association with CD4 counts, p24 antigen,
       antibiotic prophylaxis with sulfamethoxazole/trimethoprim or
       antiretroviral treatment. In 54 of 83 patients initially seronegative a
       second examination was performed after a median of 24 months (range 3-60
       months) and 2 patients had H. pylori seroconverted, indicating an
       incidence of new infection of 2%/year. In conclusion, previous reports
       have underestimated the prevalence of H. pylori infection in HIV
       patients, which seems to be similar to that in an HIV-negative
       population.
 DE    Adult  Aged  Antibodies, Bacterial/ANALYSIS  Female  Helicobacter
       pylori/IMMUNOLOGY/*ISOLATION & PURIF  Helicobacter
       Infections/*COMPLICATIONS/DIAGNOSIS  Human  HIV
       Infections/*COMPLICATIONS  Male  Middle Age  Retrospective Studies
       Serodiagnosis  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

