       Document 0312
 DOCN  M9640312
 TI    The European Collaborative Study: clinical and immunological
       characteristics of HIV 1-infected pregnant women.
 DT    9604
 AU    Thorne C; Newell ML; Dunn D; Peckham C; Epidemiology and Biostatistics
       Unit, Institute of Child Health,; London, UK.
 SO    Br J Obstet Gynaecol. 1995 Nov;102(11):869-75. Unique Identifier :
       AIDSLINE MED/96137871
 AB    OBJECTIVE: To describe the changing clinical and immunological
       characteristics and timing of diagnosis of HIV-infected pregnant women
       enrolled in the European Collaborative Study. DESIGN: A prospective
       study of the mothers of children enrolled in the European Collaborative
       Study on children born to HIV-infected women. SETTING: Twenty-one
       European centres in seven countries. SUBJECTS: One thousand six hundred
       and ninety HIV-infected women and their 1754 deliveries. RESULTS: The
       proportion of women in whom HIV infection had been diagnosed before
       pregnancy increased significantly over time, from 7% in 1984-1985 to 65%
       in 1994 (P < 0.001). The prevalence of breastfeeding, which was related
       to the timing of diagnosis, significantly declined over the study
       period. The mean CD4 count was 510 cells/mm3, and there was a
       significant decline in average CD4 count over the study period. Black
       women had a significantly lower CD4 count than white women. From
       survival analysis it is estimated that five years after delivery 14% of
       women will have died and 24% will have developed CDC stage IV disease.
       CONCLUSIONS: Timing of diagnosis is of critical importance if
       mother-to-child transmission is to be reduced through avoidance of
       breastfeeding and zidovudine therapy and effective antenatal screening
       policies have become increasingly important. The rate of progression of
       maternal disease highlights the implications of HIV infection for their
       children, both infected and uninfected.
 DE    Antiviral Agents/THERAPEUTIC USE  Breast Feeding  CD4 Lymphocyte Count
       Disease Progression  Europe/EPIDEMIOLOGY  Female  Human  HIV
       Infections/DIAGNOSIS/*EPIDEMIOLOGY/IMMUNOLOGY  Multivariate Analysis
       Pregnancy  Pregnancy Complications, Infectious/DIAGNOSIS/*EPIDEMIOLOGY/
       IMMUNOLOGY  Prevalence  Prospective Studies  Support, Non-U.S. Gov't
       Zidovudine/THERAPEUTIC USE  JOURNAL ARTICLE  MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

