       Document 0311
 DOCN  M9640311
 TI    HTLV-I associated uveitis in central Japan.
 DT    9604
 AU    Goto K; Saeki K; Kurita M; Ohno S; Division of Ophthalmology, Odawara
       Municipal Hospital, Japan.
 SO    Br J Ophthalmol. 1995 Nov;79(11):1018-20. Unique Identifier : AIDSLINE
       MED/96137905
 AB    AIMS/BACKGROUND--Recently HTLV-I has been shown to cause a kind of
       endogenous uveitis in south west Japan, where HTLV-I infection is highly
       endemic. To investigate further the association of HTLV-I infection with
       the incidence of this uveitis, HTLV-I seroprevalence in central Japan,
       where HTLV-I infection is not endemic, was studied. METHODS--HTLV-I
       seroprevalence was investigated in 1579 patients with various ocular
       diseases and 1251 normal volunteers as a younger control group. Then
       HTLV-I seroprevalence was compared in each group. RESULTS--Of 1579
       patients with various ocular diseases, 38 (2.41%) were seropositive.
       There was a statistically significant difference in HTLV-I
       seroprevalence between the undefined uveitis group and non-uveitic
       ocular diseases group (p < 0.05, Yates's correction). However, the
       seroprevalence in younger patients with undefined uveitis did not differ
       significantly from that in other groups. As regards the incidence of
       this type of uveitis, six of 12 (50%) seropositive patients, who were
       born in south west Japan and had lived in this area for 35 years,
       developed this undefined uveitis whereas only two of 26 (7.69%)
       seropositive patients in the other areas in Japan developed this
       uveitis. The difference was statistically significant (p < 0.05,
       Fisher's exact probability test). CONCLUSION--These results suggest that
       the incidence of this type of endogenous uveitis could be greatly
       influenced by environmental or hereditary factors including HLA.
 DE    Adolescence  Adult  Aged  Aged, 80 and over  Base Sequence  Child
       Child, Preschool  Female  Human  HIV Seropositivity  HTLV-I
       Infections/*EPIDEMIOLOGY/GENETICS  Incidence  Infant  Infant, Newborn
       Japan/EPIDEMIOLOGY  Male  Middle Age  Molecular Sequence Data  Sex
       Distribution  Uveitis/*EPIDEMIOLOGY/GENETICS/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

