       Document 0278
 DOCN  M9640278
 TI    Relationships between humoral factors in HIV-1-infected mothers and the
       occurrence of HIV infection in their infants.
 DT    9604
 AU    Mabondzo A; Rouvier P; Raoul H; Le Naour R; Courpotin C; Herve F;
       Parnet-Mathieu F; Lasfargues G; Dormont D; Service de Neurovirologie,
       CEA, CRSSA/DSV/DRM,; Fontenay-aux-Roses, France.
 SO    Clin Exp Immunol. 1995 Dec;102(3):476-80. Unique Identifier : AIDSLINE
       MED/96128135
 AB    Based on what is known about the biology of HIV-1 vertical transmission,
       the HIV burden of the mother, maternal immune factors and the integrity
       of the placental barrier are likely to play major roles. We therefore
       sought to determine whether the presence of antibodies in sera from 47
       HIV-1-infected mothers, including 30 non-transmitting and 17
       transmitting mothers, affected the risk of HIV-1 transmission to
       infants. Our findings showed no significant correlation between the
       capacity of antibodies to mediate antibody-dependent cell-mediated
       cytotoxicity (ADCC) and their capacity to induce protection of the child
       from HIV-1 infection (P = 0.14). Furthermore, no correlation was found
       between the capacity of maternal antibodies to neutralize in vitro
       lymphocyte or macrophage heterologous viral infection and the occurrence
       of in vivo HIV-1 infection in the infant. Sera recovered from five of 12
       transmitting mothers and from five of 11 non-transmitting mothers were
       compared in their capacity to neutralize the viruses drawn from the same
       individuals. Four out of five maternal isolates from transmitting
       mothers and all maternal isolates from non-transmitting mothers were
       sensitive to enhancement of infection mediated by the maternal serum.
 DE    Acquired Immunodeficiency Syndrome/IMMUNOLOGY/*THERAPY/  *TRANSMISSION
       Antibody-Dependent Cell Cytotoxicity  *Disease Transmission, Vertical
       Female  Human  HIV Antibodies/BLOOD  HIV-1/*IMMUNOLOGY  Pregnancy
       Pregnancy Complications, Infectious/*IMMUNOLOGY  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

