       Document 0267
 DOCN  M9640267
 TI    Rate of detection of human herpesvirus-6 at different stages of HIV
       infection.
 DT    9604
 AU    Gautheret A; Aubin JT; Fauveau V; Rozenbaum W; Huraux JM; Agut H;
       Laboratoire de Virologie, Centre National de Recherche; Scientifique,
       CERVI, Groupe Hospitalier Pitie-Salpetriere,; Paris, France.
 SO    Eur J Clin Microbiol Infect Dis. 1995 Sep;14(9):820-4. Unique Identifier
       : AIDSLINE MED/96120956
 AB    In a cross-sectional study, human herpesvirus-6 (HHV-6) infection was
       analysed by means of polymerase chain reaction in peripheral blood
       mononuclear cells (PBMCs) and saliva from 125 HIV-seropositive subjects
       and 29 HIV-seronegative controls. HHV-6 was detected in saliva
       significantly more frequently in HIV-seronegative subjects than in
       HIV-seropositive subjects (p = 0.023), with no significant difference
       between HIV-seropositive subgroups. The HIV proviral copy number in
       PBMCs differed significantly according to HIV subgroup, as expected, but
       did not differ according to either the presence of HHV-6 or the number
       of HHV-6 copies in PBMCs. All the HHV-6 identified were variant B except
       for one variant A strain detected in saliva from a healthy subject.
       These results do not support the hypothesis that there is synergistic
       activation of HHV-6 infection in the course of HIV infection.
 DE    Cross-Sectional Studies  DNA, Viral/ANALYSIS  Herpesvirus 6,
       Human/*ISOLATION & PURIF  Human  HIV Infections/*VIROLOGY  Leukocytes,
       Mononuclear/VIROLOGY  Saliva/VIROLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

