       Document 0266
 DOCN  M9640266
 TI    Activated CD4+ and CD8+ cells in the colonic mucosa of ulcerative
       colitis patients: their relationship to HLA-DR antigen expression on the
       colonic epithelium and serum soluble CD25 levels.
 DT    9604
 AU    Sasakawa T; Takizawa H; Bannai H; Narisawa R; Asakura H; 3rd Department
       of Internal Medicine, Niigata University School of; Medicine, Japan.
 SO    Digestion. 1995;56(6):516-22. Unique Identifier : AIDSLINE MED/96127519
 AB    This study was performed to clarify the relationship between activated
       (HLA-DR-expressing) CD4+ and CD8+ cells in the colonic lamina propria of
       ulcerative colitis and other immunological factors, i.e., epithelial DR
       expression, serum soluble CD25 levels, and colonic mucosal CD25+ cells.
       The frequency of epithelial DR expression was positively correlated with
       the numbers of CD4+ and CD8+ cells. The percentages activated CD4+/CD4+
       cells were higher in mucosae with DR- epithelium than in mucosae with
       DR+ epithelium. The serum soluble CD25 levels were increased in
       ulcerative colitis, and there was an inverse correlation between these
       levels and the relative number of activated CD4+ cells in untreated
       active disease. These results suggest that interactions among mucosal
       CD4+ cells, colonic epithelium, and serum soluble CD25 might play an
       important role in the pathogenesis of ulcerative colitis.
 DE    Adolescence  Adult  Aged  Colitis, Ulcerative/*IMMUNOLOGY
       Colon/*IMMUNOLOGY  CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Enzyme-Linked Immunosorbent Assay  Female
       Human  HLA-DR Antigens/*ANALYSIS  Immunohistochemistry  Intestinal
       Mucosa/*IMMUNOLOGY  Lymphocyte Count  Lymphocyte Transformation  Male
       Middle Age  Receptors, Interleukin-2/*ANALYSIS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

