       Document 0264
 DOCN  M9640264
 TI    Gastric toxoplasmosis in acquired immunodeficiency syndrome: antemortem
       diagnosis with histopathologic characterization.
 DT    9604
 AU    Alpert L; Miller M; Alpert E; Satin R; Lamoureux E; Trudel L; Department
       of Medicine, Jewish General Hospital, Montreal,; Quebec, Canada.
 SO    Gastroenterology. 1996 Jan;110(1):258-64. Unique Identifier : AIDSLINE
       MED/96121015
 AB    Gastrointestinal symptoms attributable to Toxoplasma gondii infection
       are distinctly unusual, and antemortem diagnosis of gastrointestinal
       involvement is rarely documented, particularly in the absence of
       cerebral manifestations or disseminated disease. This case report
       describes a rare example of T. gondii infection of the stomach diagnosed
       antemortem in a 22-year-old Haitian woman with acquired immunodeficiency
       syndrome (AIDS) who presented with fever and abdominal pain. An
       abdominal computerized tomographic scan showed thickened gastric walls.
       Endoscopy showed diffusely thickened gastric folds and a fundic ulcer
       along the greater curvature. Light and electron-microscopic examination
       of gastric mucosal biopsy specimens showed active Toxoplasma infection
       with necrosis and intracellular trophozoites within the gastric
       epithelium, smooth muscle cells, macrophages, and endothelial cells.
       Both true cysts and pseudocysts were seen. Disseminated disease was
       documented by the growth of T. gondii in a tissue culture from a venous
       blood sample. It is concluded that some patients with AIDS, particularly
       those from areas endemic for Toxoplasma infection, can manifest
       disseminated disease in unusual locations such as the gastrointestinal
       tract. Documentation of active T. gondii infection based on tissue
       cultures of venous blood or on biopsy specimens of symptomatic
       extracerebral sites can lead to a rapid diagnosis of toxoplasmosis, a
       treatable disease.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Case Report
       Female  Human  Stomach Diseases/*COMPLICATIONS/DIAGNOSIS/*PATHOLOGY
       Tomography, X-Ray Computed
       Toxoplasmosis/*COMPLICATIONS/DIAGNOSIS/*PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

