       Document 0254
 DOCN  M9640254
 TI    Further evidence for the relationship of HIV-1 gp120 V3 loops with Ig
       superfamily members: similarity with the putative CDR3 region of T-cell
       receptor delta-chains.
 DT    9604
 AU    Metlas R; Skerl V; Veljkovic V; Pongor S; Laboratory for
       Multidisciplinary Research, Institute for Nuclear; Sciences Vinca,
       Belgrade, Yugoslavia.
 SO    Immunol Lett. 1995 Jul-Aug;47(1-2):25-8. Unique Identifier : AIDSLINE
       MED/96087575
 AB    Twenty-five V3 loops of envelope gp 120 extracted from 30 HIV-1 isolates
       were compared with T-cell receptor (TCR) subunits variable (V) portions
       using pairwise alignments of 11-residue peptides. The results indicate
       that, in comparison with random sequences, the analyzed V3 loops, unlike
       control (unrelated) sequences, display highly significant local
       similarity with TCR V delta (p approximately 10(-20)). However,
       pattern-matching searches were performed on a much larger number of V3
       loops (484). In particular, selective pattern TR * * * NT * K * I is
       shared by V delta from human T-cell line KT19E and 230 HIV-1 V3 loops
       (N-terminal portion). Pattern RA * YT * * * I * G is common for V delta
       chain isolated from T-cell line DS6 of an immunodeficient patient and 69
       V3 loops (C-terminal portion). The presented delta-chain portions of
       sequence similarity with the V3 loops overlap the putative
       complementarity-determining region (CDR3), thus possibly indicating
       functional similarity too.
 DE    Amino Acid Sequence  Human  HIV Envelope Protein
       gp120/*CHEMISTRY/*IMMUNOLOGY  HIV-1/*IMMUNOLOGY  Immunoglobulin Variable
       Region/*CHEMISTRY  Major Histocompatibility Complex/IMMUNOLOGY
       Molecular Sequence Data  Receptors, Antigen, T-Cell,
       gamma-delta/*CHEMISTRY/*IMMUNOLOGY  *Sequence Homology, Amino Acid
       Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

