       Document 0248
 DOCN  M9640248
 TI    Acquired resistance in Mycobacterium avium complex strains isolated from
       AIDS patients and beige mice during treatment with clarithromycin.
 DT    9604
 AU    Doucet-Populaire F; Truffot-Pernot C; Grosset J; Jarlier V; Laboratoire
       de Bacteriologie-Virologie, Faculte de Medecine; Pitie-Salpetriere,
       Paris, France.
 SO    J Antimicrob Chemother. 1995 Jul;36(1):129-36. Unique Identifier :
       AIDSLINE MED/96051684
 AB    Clarithromycin has been reported to select clarithromycin resistant
       mutants of Mycobacterium avium complex (MAC) during treatment with
       clarithromycin in AIDS patients and beige mice. We selected resistant
       mutants in vitro at a frequency of 5 x 10(-9). Clarithromycin resistant
       strains of MAC isolated in AIDS patients and beige mice as well as
       derivatives selected in vitro had a unique pattern of acquired
       cross-resistance to macrolides and related antibiotics. In contrast, the
       pattern of resistance to non-macrolide antibiotics remained unchanged in
       clarithromycin resistant strains. A dramatic decrease in ribosome
       affinity for clarithromycin and erythromycin was found in clarithromycin
       resistant strains, but no mutation was found in the peptidyl domain of
       the 23S rRNA, indicating that another ribosomal modification is
       involved.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Animal  Antibiotics,
       Macrolide/METABOLISM/*PHARMACOLOGY/*THERAPEUTIC USE  Base Sequence
       Clarithromycin/METABOLISM/*PHARMACOLOGY/*THERAPEUTIC USE  Drug
       Resistance, Microbial  Erythromycin/METABOLISM  Human  Mice  Mice,
       Inbred Strains  Microbial Sensitivity Tests  Molecular Sequence Data
       Mutation  Mycobacterium avium Complex/*DRUG EFFECTS/GENETICS
       Mycobacterium avium-intracellulare Infection/DRUG THERAPY/
       *MICROBIOLOGY  Peptidyl Transferases/GENETICS/METABOLISM  Ribosomes/DRUG
       EFFECTS/METABOLISM  RNA, Messenger/BIOSYNTHESIS  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

