       Document 0243
 DOCN  M9640243
 TI    Role of apoptosis in HIV disease pathogenesis.
 DT    9604
 AU    Oyaizu N; Pahwa S; Department of Pediatrics, North Shore University
       Hospital-Cornell; University Medical College, Manhasset, New York, New
       York 11030,; USA.
 SO    J Clin Immunol. 1995 Sep;15(5):217-31. Unique Identifier : AIDSLINE
       MED/96108690
 AB    After approximately one and a half decades of intensive studies, the
       exact mechanisms to explain HIV-mediated cytopathicity are still
       enigmatic and need closer scrutiny. There has been a dichotomy between
       virological and immunological viewpoints in understanding HIV-mediated
       cytopathicity, the former emphasizing a killing of infected cells by
       HIV-1 and the latter emphasizing indirect mechanisms wherein HIV or its
       soluble component(s) alter CD4 T-cell function and induce susceptibility
       to apoptosis. Accumulating evidence points to the notion that apoptosis
       might be a major contributor to the depletion of CD4 T-cells in HIV
       infection. This review summarizes current information about the
       regulatory mechanisms of T-cell apoptosis and the role of apoptosis in
       HIV pathogenesis with the goal of providing an integrated view of HIV
       cytopathicity.
 DE    Animal  Apoptosis/*PHYSIOLOGY  Human  HIV Infections/ETIOLOGY/*PATHOLOGY
       Support, U.S. Gov't, P.H.S.  T-Lymphocytes/PATHOLOGY  JOURNAL ARTICLE
       REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

