       Document 0232
 DOCN  M9640232
 TI    A community-based study of human immunodeficiency virus type 2 provirus
       load in rural village in West Africa.
 DT    9604
 AU    Ariyoshi K; Berry N; Wilkins A; Ricard D; Aaby P; Naucler A; Ngom PT;
       Jobe O; Jaffar S; Dias F; Tedder RS; Whittle H; Medical Research Council
       Laboratories, Banjul, Gambia.
 SO    J Infect Dis. 1996 Jan;173(1):245-8. Unique Identifier : AIDSLINE
       MED/96132490
 AB    A community-based study of provirus load in human immunodeficiency virus
       (HIV) type 2-infected subjects was done in a rural village in
       Guinea-Bissau. HIV-2 provirus load varied considerably, with a geometric
       mean of 124.3 (95% confidence interval, 86.0-179.6) copies/10(5) CD4
       cells, which is a level similar to that found in HIV-1 infection.
       Neither malaria parasitemia, active syphilis, or human T cell leukemia
       virus coinfection significantly influenced provirus load, nor did age.
       Eleven of 104 HIV-2-infected subjects had died after 3 years of
       follow-up; 9 of those who died had a high provirus load of > or = 100
       copies/10(5) CD4 cells and a relatively low CD4 cell percentage of <
       29%.
 DE    Adult  Age Factors  Cohort Studies  CD4 Lymphocyte Count  DNA,
       Viral/ANALYSIS  Female  Guinea-Bissau/EPIDEMIOLOGY  Human  HIV
       Infections/COMPLICATIONS/*EPIDEMIOLOGY  *HIV Seroprevalence
       *HIV-2/PHYSIOLOGY  HTLV-I Infections/COMPLICATIONS
       Malaria/COMPLICATIONS  Male  Middle Age  Polymerase Chain Reaction
       Prospective Studies  *Proviruses/PHYSIOLOGY  Rural Population/STATISTICS
       & NUMER DATA  Support, Non-U.S. Gov't  Syphilis/COMPLICATIONS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

