       Document 0231
 DOCN  M9640231
 TI    Frequent presence of a novel herpesvirus genome in lesions of human
       immunodeficiency virus-negative Kaposi's sarcoma.
 DT    9604
 AU    Chuck S; Grant RM; Katongole-Mbidde E; Conant M; Ganem D; Howard Hughes
       Medical Institute, University of California, San; Francisco 94143, USA.
 SO    J Infect Dis. 1996 Jan;173(1):248-51. Unique Identifier : AIDSLINE
       MED/96132491
 AB    While Kaposi's sarcoma (KS) is extremely common in homosexual men
       infected with human immunodeficiency virus (HIV), it is also found in
       several clinical settings in which HIV infection is absent. Recently,
       sequences from the genome of a novel member of the herpesvirus family
       have been identified within KS biopsies in the AIDS-associated form of
       the disease. The presence of these sequences was sought in 6 cases of
       HIV-negative KS, including 4 cases of endemic KS from Africa, and was
       found in 5 of the 6. These findings strengthen the association between
       infection with this virus and the development of KS and argue against
       the notion that this association is simply the result of opportunistic
       superinfection of profoundly immunodeficient hosts.
 DE    Adult  Base Sequence  DNA Primers/CHEMISTRY  DNA, Viral/ANALYSIS
       Electrophoresis, Agar Gel  *Genome, Viral  Herpesviridae/*GENETICS
       Herpesviridae Infections/*COMPLICATIONS  Human  *HIV Seronegativity
       Male  Middle Age  Molecular Sequence Data  North America  Opportunistic
       Infections/*COMPLICATIONS  Polymerase Chain Reaction  Sarcoma,
       Kaposi's/*VIROLOGY  Skin/VIROLOGY  Skin Neoplasms/*VIROLOGY  Support,
       Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.  Uganda  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

