       Document 0230
 DOCN  M9640230
 TI    Disseminated Mycobacterium avium complex infection in AIDS:
       immunopathogenic significance of an activated tumor necrosis factor
       system and depressed serum levels of 1,25 dihydroxyvitamin D.
 DT    9604
 AU    Haug CJ; Aukrust P; Lien E; Muller F; Espevik T; Froland SS; Medical
       Department A, Univeristy of Oslo, Norway.
 SO    J Infect Dis. 1996 Jan;173(1):259-62. Unique Identifier : AIDSLINE
       MED/96132494
 AB    Disseminated Mycobacterium avium complex (MAC) infection is associated
       with considerable morbidity and mortality in patients with AIDS. Because
       both tumor necrosis factor-alpha (TNF-alpha) and 1,25-dihydroxyvitamin
       D3 (1,25D) may be involved in the normal control of MAC infection, these
       parameters were studied in AIDS patients with disseminated MAC
       infection. Of 53 AIDS patients studied, 24 had no clinical events, 11
       had disseminated MAC infection, and 18 had other clinical events.
       Patients with disseminated MAC infection had significantly higher serum
       levels of both TNF-alpha and soluble TNF receptors compared with other
       AIDS patients; almost half of the MAC-infected patients had TNF
       bioactivity in serum. MAC-infected patients also had severely decreased
       serum 1,25D levels compared with all other AIDS patients. The activation
       of the TNF system was significantly correlated with the degree of 1,25D
       deficiency. These findings may reflect interaction between vitamin D and
       the TNF system in the pathophysiology of disseminated MAC infection in
       AIDS.
 DE    AIDS-Related Opportunistic Infections/*IMMUNOLOGY  Calcitriol/*BLOOD
       CD4-Positive T-Lymphocytes/IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Human  *HIV-1  Mycobacterium avium
       Complex/IMMUNOLOGY  Mycobacterium avium-intracellulare
       Infection/*IMMUNOLOGY  Prospective Studies  Receptors, Tumor Necrosis
       Factor/ANALYSIS  Support, Non-U.S. Gov't  Tumor Necrosis
       Factor/*ANALYSIS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

