       Document 0228
 DOCN  M9640228
 TI    Evidence for genetic regulation of susceptibility to toxoplasmic
       encephalitis in AIDS patients.
 DT    9604
 AU    Suzuki Y; Wong SY; Grumet FC; Fessel J; Montoya JG; Zolopa AR; Portmore
       A; Schumacher-Perdreau F; Schrappe M; Koppen S; Ruf B; Brown BW;
       Remington JS; Department of Immunology and Infectious Diseases, Palo
       Alto; Medical Foundation, CA 94301, USA.
 SO    J Infect Dis. 1996 Jan;173(1):265-8. Unique Identifier : AIDSLINE
       MED/96132496
 AB    The frequency of HLA-DQ antigens in AIDS patients with toxoplasmic
       encephalitis (TE) were examined. HLA-DQ3 was significantly more frequent
       in white North American AIDS patients with TE (85.0%) than in the
       general white population (51.8%; P = .007, corrected P = .028) or
       randomly selected control AIDS patients who had not developed TE (40.0%;
       P = .016). In contrast, the frequency of HLA-DQ1 was lower in TE
       patients than in healthy controls (40.0% vs. 66.5%, P = .027), but this
       difference did not reach statistical significance when corrected for the
       number of variables tested (corrected P = .108 for the general white
       population). HLA-DQ3 thus appears to be a genetic marker of
       susceptibility to development of TE in AIDS patients, and DQ1 may be a
       resistance marker. These HLA associations with disease indicate that
       development of TE in AIDS patients is affected by a gene or genes in the
       HLA complex and that HLA-DQ typing may help in decisions regarding TE
       prophylaxis.
 DE    AIDS-Related Opportunistic Infections/*GENETICS/IMMUNOLOGY  CD4
       Lymphocyte Count  CD4-Positive T-Lymphocytes/IMMUNOLOGY  Disease
       Susceptibility  Encephalitis/*GENETICS  *Gene Frequency  Genetic Markers
       Genotype  Human  HLA-DQ Antigens/*GENETICS  Support, Non-U.S. Gov't
       Support, U.S. Gov't, P.H.S.  Toxoplasmosis, Cerebral/*GENETICS  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

