       Document 0227
 DOCN  M9640227
 TI    Impairment of tetanus toxoid-specific Th1-like immune responses in
       humans infected with Schistosoma mansoni.
 DT    9604
 AU    Sabin EA; Araujo MI; Carvalho EM; Pearce EJ; Department of Microbiology
       and Immunology, College of Veterinary; Medicine, Cornell University,
       Ithaca, New York 14853-6401, USA.
 SO    J Infect Dis. 1996 Jan;173(1):269-72. Unique Identifier : AIDSLINE
       MED/96132497
 AB    After vaccination with tetanus toxoid (TT), TT-specific immune responses
       in humans infected with Schistosoma mansoni were assessed. Peripheral
       blood mononuclear cells (PBMC) from vaccinated infected subjects and
       vaccinated uninfected controls were evaluated for their ability to
       produce cytokines characteristic of Th1 or Th2 cells (interferon
       [IFN]-gamma or interleukin [IL]-4, respectively) after in vitro
       restimulation with TT. TT-specific IFN-gamma production by PBMC from
       infected subjects was inversely related to infection intensity and was
       significantly lower than TT-specific IFN-gamma production by control
       PBMC. PBMC from all of the infected subjects and 3 of the 5 controls
       analyzed by reverse transcriptase-polymerase chain reaction transcribed
       the IL-4 gene in response to TT restimulation. Together, these results
       suggest that S. mansoni-infected persons mount a Th2-like response to
       the bystander antigen TT, while uninfected persons mount a Th1- or
       Th0-like response.
 DE    Adolescence  Adult  Animal  Cells, Cultured  Child  Electrophoresis,
       Agar Gel  Female  Human  Interferon Type II/BIOSYNTHESIS
       Interleukin-4/BIOSYNTHESIS  Leukocytes, Mononuclear/*IMMUNOLOGY
       Lymphocyte Transformation  Male  Middle Age  Polymerase Chain Reaction
       Schistosoma mansoni/IMMUNOLOGY  Schistosomiasis mansoni/*IMMUNOLOGY
       Support, U.S. Gov't, P.H.S.  Tetanus/PREVENTION & CONTROL  Tetanus
       Toxoid/*IMMUNOLOGY  Th1 Cells/*IMMUNOLOGY  Th2 Cells/IMMUNOLOGY
       *Vaccination  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

